Download The stem cell hope : how stem cell medicine can change our by Alice Park PDF

By Alice Park

A landmark publication by way of the senior technological know-how author at Time magazine introduces us to a scientific step forward which can store our lives. 

Few humans be aware of a lot approximately stem cellphone study past the moral questions raised through the use of embryos. yet within the final decade, stem mobile study has made large advances towards taking out a few of our such a lot intractable illnesses. Now this sweeping and available e-book introduces us to this state of the art technological know-how that might revolutionize drugs and alter the best way we expect approximately and deal with disease. 

Alice Park takes us from stem cell's debatable beginnings to the new electrifying promise of having the ability to create the flexible cells with no utilizing embryos in any respect. She indicates us how stem cells supply researchers an unparalleled skill to check illness whereas giving sufferers the promise of changing diseased cells with fit new ones. and he or she profiles the scientists and leaders-many with their very own compelling stories-who have fueled the search and should proceed to form the sector in future years.

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This leads to the production of a truncated lamin A protein (progerin) with an internal deletion of 50 amino acids in the C-terminal globular domain. As a result of this mutation, progerin, but not mature lamin A, retains a C-terminal farnesyl tail that is normally only transiently present in the Lamin A precursor. , 2008). , 2008). Interestingly, the same aberrant splicing event may also occur at much lower levels in normal cells (Scaffidi and Misteli, 2006). , 2007; Scaffidi and Misteli, 2006), possibly reflecting a low turnover of the protein or an age-related inability to remove cells with high progerin loads.

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Cell 132, 681–696. , et al. (2008). High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs. Proc. Natl. Acad. Sci. USA 105, 17079–17084. , et al. (2010). Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death. Nat. Cell Biol. 12, 572–582. J. (2007). Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss.

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