Download Comparative Genomics: Empirical and Analytical Approaches to by David Sankoff, Joseph H. Nadeau (auth.), David Sankoff, PDF

By David Sankoff, Joseph H. Nadeau (auth.), David Sankoff, Joseph H. Nadeau (eds.)

A entire account of genomic rearrangement, concentrating on the mechanisms of inversion, translocation, gene and genome duplication and gene move and at the styles that outcome from them in comparative maps. comprises analyses of genomic sequences in organelles, prokaryotes and eukaryotes in addition to comparative maps of the nuclear genomes in larger vegetation and animals. The ebook showcases numerous algorithmic and statistical techniques to rearrangement and map data.

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Additional info for Comparative Genomics: Empirical and Analytical Approaches to Gene Order Dynamics, Map Alignment and the Evolution of Gene Families

Example text

KASAHARA, M. 1997. New insights into the genomic organization and origin of the major histocompatibility complex: role of chromosomal (genome) duplication in the emergence of the adaptive immune system. Hereditas 127:59-65. KASAHARA, M. , AND ISHIBASHI, T. 1996. Chromosomal localization of the proteasome z subunit gene reveals an ancient chromosomal duplication involving the major histocompatibility complex. Proceedings of the National Academy of Sciences USA 93:9096-9101. KELLER, M. , SEIFRIED, B.

If similar estimates are found for other human chromosomes, it would suggest more than an one hundred fold increase in the amount of recently duplicated material in the human when compared to that of the worm and other metazoans. The molecular basis for these differences in genomic architecture is unknown. It will be interesting to compare the organization of the mouse genome, in this regard, to determine if recent inter and intrachromosomal duplications may be a property of other mammalian species.

Between these two subspecies. Selection apparently maintains the chromosomal difference, because each of the two chromosomal types occurs in a discrete geographic range. The same geographic structure has not been observed for sequence variation in the nuclear genome (Table 1), as is expected if genetic drift was responsible for establishing the cline. , the shape of the chromosomal cline) is partially determined by the strength of the selection pressure that maintains the zone, either by selection against hybrid individuals or by selection for alternative genotypes on opposite sides of the zone (Barton and Hewitt, 1989).

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